Sidebar 10: Percentage of U.S. Adults Who Smoked Cigarettes in 2021.......................................................................................... 41 Sidebar 11: Physical Activity Guidelines.................................................................................................................................................... 43 Sidebar 12: Making Healthy Food Choices: Nutrition Labels.............................................................................................................. 45 Sidebar 13: Guidelines for Alcohol Consumption................................................................................................................................... 46 Sidebar 14: Ways to Protect Your Skin...................................................................................................................................................... 47 Sidebar 15: Ways to Reduce Cancer Risk from Pathogens................................................................................................................. 49 Sidebar 16: HPV Vaccination Recommendations................................................................................................................................... 50 Sidebar 17: Occupation and Cancer Risk in Firefighters...................................................................................................................... 52 Sidebar 18: USPSTF-recommended Tests to Screen for Cancer........................................................................................................ 56 Sidebar 19: Benefits and Potential Harms of Cancer Screening........................................................................................................ 57 Sidebar 20: The USPSTF Grading System for Cancer Screening Guidelines.................................................................................. 59 Sidebar 21: USPSTF Guidelines for Cancer Screening.......................................................................................................................... 60 Sidebar 22: Inequities in Cancer Screening.............................................................................................................................................. 63 Sidebar 23: Evidence-based Interventions to Increase Adherence to Cancer Screening........................................................... 64 Sidebar 24: Artificial Intelligence in Early Cancer Detection............................................................................................................... 66 Sidebar 25: What Is Medical Research?..................................................................................................................................................... 69 Sidebar 26: Therapeutic Development....................................................................................................................................................... 70 Sidebar 27: Types of Clinical Trials............................................................................................................................................................... 71 Sidebar 28: Disparities in Clinical Trial Participation.............................................................................................................................. 74 Sidebar 29: Telemedicine in Cancer Care.................................................................................................................................................. 75 Sidebar 30: Disparities in Cancer Treatment............................................................................................................................................ 78 Sidebar 31: Using Surgery for Cancer Treatment................................................................................................................................... 79 Sidebar 32: Commonly Used Terms and Benchmarks in Clinical Studies....................................................................................... 80 Sidebar 33: Using Radiation in Cancer Treatment................................................................................................................................... 81 Sidebar 34: Companion Diagnostics........................................................................................................................................................... 85 Sidebar 35: The Challenge of Treatment Resistance............................................................................................................................. 87 Sidebar 36: The Challenges Posed by Rare Cancers.............................................................................................................................. 90 Sidebar 37: Recent Advances Against Blood Cancers.......................................................................................................................... 94 Sidebar 38: Key Cells of the Immune System........................................................................................................................................ 100 Sidebar 39: T Cell-based Adoptive Cell Therapy.................................................................................................................................... 116 Sidebar 40: CAR T-cell Therapies Approved by the U.S. Food and Drug Administration.......................................................... 117 Sidebar 41: Clinical Trials Testing Immunotherapy Combinations with Other Modalities.......................................................... 131 Sidebar 42: Phases of Cancer Survivorship............................................................................................................................................. 134 Sidebar 43: Fertility Preservation After a Diagnosis of Cancer......................................................................................................... 137 Sidebar 44: What Is Palliative Care?.......................................................................................................................................................... 139 Sidebar 45: Helping Patients with Cancer Through Psycho-oncology Research......................................................................... 139 Sidebar 46: Coping with Posttraumatic Stress After a Cancer Diagnosis..................................................................................... 140 AACR Cancer Progress Report 2023 v
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